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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#_3 http://www.w3.org/ns/prov#value Osteoinductive factor (OIF) is a glycoprotein in bone that induces ectopic bone formation. Implantation of OIF plus transforming growth factor beta (TGF-beta) type 1 or 2 into subcutaneous tissues of rats induces formation of bone at the implantation site. Since TGF-beta is also present in bone matrix and inhibits formation of multinucleated cells that express an osteoclast phenotype in long-term human marrow cultures, we tested the effects of OIF on formation of these osteoclast-like cells to determine the effects of OIF on cells in the osteoclast lineage. We found that OIF inhibited total multinucleated cell (MNC) formation in a dose-dependent fashion and preferentially inhibited formation of MNCs that react with monoclonal antibody 23c6 (23c6-positive MNCs), an antibody that identifies osteoclasts. In addition, low concentrations of OIF in combination with low concentrations of TGF-beta acted synergistically to inhibit 23c6-positive MNC formation. The inhibition of 23c6-positive MNC formation by OIF was not mediated by prostaglandin synthesis. These data suggest that regulatory growth factors, such as OIF or TGF-beta, that are stored within the bone matrix and released when bone is resorbed can serve as natural inhibitors of osteoclast activity by inhibiting osteoclast formation. http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/2326263 http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/2326263 http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#_3 http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo#pubinfo http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo http://purl.org/dc/terms/created 2014-07-03T14:33:41.710+02:00 http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA_FitJY-n8t7RNXILNy6gZpKG1pTGiztqM0QfG_8CqFo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234