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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#_5 http://www.w3.org/ns/prov#value Hyperosmotic stress (0±5 M sorbitol) in combination with protein Ser}Thr phosphatase inhibition (0±2 lM okadaic acid) induced a prolonged activation of 46 and 54 kDa SAPKs in cytosolic extracts of ventricular myocytes (Figure 1A). The order of potency of SAPK activation was studied by the in-gel kinase assay. Cells were exposed to 0±5 M sorbitol (S), 0±5 M sorbitol­0±2 lM okadaic acid (SOA), 0±2 lM okadaic acid (OA) or 50 ng/ml anisomycin (A) for 30 min at 37 °C. Okadaic acid (0±2 lM) alone caused only a marginal stimulation but enhanced the response to sorbitol.SAPK activity was immunoprecipitated from nuclear extracts of cells exposed to 0±5 M sorbitol­0±2 lM okadaic acid using a JNK1 antibody (Figure 1C). http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9271103 http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9271103 http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#_5 http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM http://purl.org/dc/terms/created 2014-07-03T14:34:00.695+02:00 http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234