@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAZvTO1wrmCdWJajTHtobPmLysXAvuLUJezukQNQj0ZIM#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix schem: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: hgnc:6881;
    a Protein: .
  
  sub:_3 rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject schem:Sorbitol;
    a rdf:Statement .
  
  sub:_4 occursIn: obo:CL_0000187, obo:UBERON_0002082, species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject chebi:7733;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:\"okadaic acid\") -> (a(SCHEM:Sorbitol) -> kin(p(HGNC:MAPK8)))",
      "a(SCHEM:Sorbitol) -> kin(p(HGNC:MAPK8))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_5 prov:value "Hyperosmotic stress (0±5 M sorbitol) in combination with protein Ser}Thr phosphatase inhibition (0±2 lM okadaic acid) induced a prolonged activation of 46 and 54 kDa SAPKs in cytosolic extracts of ventricular myocytes (Figure 1A). The order of potency of SAPK activation was studied by the in-gel kinase assay. Cells were exposed to 0±5 M sorbitol (S), 0±5 M sorbitol­0±2 lM okadaic acid (SOA), 0±2 lM okadaic acid (OA) or 50 ng/ml anisomycin (A) for 30 min at 37 °C. Okadaic acid (0±2 lM) alone caused only a marginal stimulation but enhanced the response to sorbitol.SAPK activity was immunoprecipitated from nuclear extracts of cells exposed to 0±5 M sorbitol­0±2 lM okadaic acid using a JNK1 antibody (Figure 1C).";
    prov:wasQuotedFrom pubmed:9271103 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:9271103;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:34:00.695+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}