@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAZu3h3H7YuSHDWGUOcljEIQddYMbE_3wmJKLd-fmcSBg> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAZu3h3H7YuSHDWGUOcljEIQddYMbE_3wmJKLd-fmcSBg#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 belv:variantOf hgnc:4617 ;
    a proteinModification: , psimod:00696 .
  sub:_2 hasAgent: sub:_3 ;
    a go:0016301 .
  sub:_3 geneProductOf: hgnc:4617 ;
    a Protein: .
  sub:_4 occursIn: species:9606 ;
    rdf:object sub:_2 ;
    rdf:predicate belv:directlyDecreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "p(HGNC:GSK3B,pmod(P,S,9)) =| kin(p(HGNC:GSK3B))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "20131211" .
  sub:_5 prov:value ". A major mechanism of cell necrosis is the opening of the mitochondrial permeability transition pore (mPTP), which consists of multiple protein subunits, including adenine nucleotide translocase (ANT). The threshold for mPTP opening is elevated by phosphorylation of GSK-3beta at Ser9, which reduces activity of this kinase. {FROM FULL TEST: The mPTP is a non-selective large conductance channel in the mitochondrial inner membrane, which is physiologically closed. Opening of mPTPs is involved in cell death induced by a variety of causes (for example, ischemia/reperfusion, alcohol, endotoxin, anti-cancer agents), therefore 'opening' is modeled as tportof(mitochondrial permeability transition pore) and increased threshold for opening is modeled as decrease in tportof -SE}" ;
    prov:wasQuotedFrom pubmed:19506320 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:19506320 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:33:34.806+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}