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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZs3Ob1BnyUQTewlponhui3j1CH03VnoyvLZU4skgZfM#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAZs3Ob1BnyUQTewlponhui3j1CH03VnoyvLZU4skgZfM#_4 http://www.w3.org/ns/prov#value The two main CYP enzymes that are up-regulated by cigarette smoke are CYP1A1 and CYP1B1, which are regulated by ER{alpha} (18). Stimulation of estrogen receptor in the lungs increases protein expression of CYP1A1 by twofold (17). The increased CYP expression is also related to increased estradiol-? expression (19). 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