http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#Head http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#assertion http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#provenance http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#assertion http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_2 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5013 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0001969 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/Iron http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_1 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#assertion http://www.w3.org/2000/01/rdf-schema#label cat(p(HGNC:HMOX1)) -> a(SCHEM:Iron) http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_4 http://www.w3.org/ns/prov#value C. Traditional View on Heme Oxygenase and Its Toxic Breakdown Products Traditionally, HO has been thought to be solely involved in the breakdown of heme from senescent red blood cells or denatured heme proteins. The degradation products free iron, biliverdin/bilirubin, and CO produced during this useful process were considered \"toxic waste\" materials (Johnson et al., 1999). Free iron(II) (Fe2+) is capable of causing severe oxidative stress by the generation of reactive molecules, such as the highly reactive hydroxyl radical, since it can participate in Fenton reaction, which involves H2O2 and iron reacting with a variety of organic molecules, resulting in a series of radical reactions (Tyrrell, 1999; Alayash et al., 2001). This oxidative stress might then result in membrane damage and consequently tissue injury. Iron is thus generally considered a powerful prooxidant and injurious to cells. http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12869663 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12869663 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#_4 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg http://purl.org/dc/terms/created 2014-07-03T14:32:04.804+02:00 http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZo4VzlerT1P6T5KheyHv5OqxXaXu3Wxr8y74Afe-nWg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234