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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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FceRI stimulation resulted in the activation of Syk, which targeted numerous substrates in mast cells (33). Tyrosine phosphorylation of Vav (a Sykdependent event) was sufficient for the activation of Rac1, but not of Ras. Vav-mediated activation of Rac1 resulted in the induction of JNK1 activity and increased levels of IL-2 and IL-6 mRNAs. Inhibition of Rac1 or JNK1 activity resulted in inhibition of the studied IL-6 response.
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