@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAZbzV0hJKiRS7zRlQgPPwyd9PRvCYvYkKFc7u678ih2I> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAZbzV0hJKiRS7zRlQgPPwyd9PRvCYvYkKFc7u678ih2I#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: hgnc:6877;
    a Protein: .
  
  sub:_3 belv:hasSubstitution "G,12,V";
    belv:variantOf hgnc:5173;
    a proteinModification: .
  
  sub:_4 geneProductOf: hgnc:1784;
    a Protein: .
  
  sub:_5 rdf:object sub:_4;
    rdf:predicate belv:increases;
    rdf:subject sub:_3;
    a rdf:Statement .
  
  sub:_6 occursIn: obo:CL_0000192, obo:UBERON_0004535, species:9606;
    rdf:object sub:_5;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "kin(p(HGNC:MAPK3)) -> (p(HGNC:HRAS,sub(G,12,V)) -> p(HGNC:CDKN1A))",
      "p(HGNC:HRAS,sub(G,12,V)) -> p(HGNC:CDKN1A)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_8;
    pav:version "20131211" .
  
  sub:_7 prov:value "Increased expression of p53, p21, and p16 by H-rasV12 transduction was effectively inhibited by PD98059 (P0.05 for p53 and p21, P0.01 for p16 versus Ras) but not by either LY294002 or SB203580 (Figure 2C and Data Supplement Figure V).";
    prov:wasQuotedFrom pubmed:14557365 .
  
  sub:_8 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:14557365;
    prov:wasDerivedFrom beldoc:, sub:_7 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:10.022+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}