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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#_4 http://www.w3.org/ns/prov#value To examine how BATF-mediated negative control of AP-1 activity influences specific transitions in thymic T cell development, the p56lck proximal promoter was used to drive expression of an HA Ag-tagged BATF protein in mice. Two founder animals positive for the transgene were bred to generate the FVB-lck line 2 and FVB-lck line 4 mice used in these studies (Fig. 1A). To determine whether the overexpression of BATF influences cytokine gene expression, thymocytes and splenocytes from wild-type and transgenic FVB-lck line 2 littermates were stimulated in vitro with plate-bound anti-CD3{epsilon} mAb. Total RNA was isolated after 24 h, and RPA was performed. The induction of IL-2, IL-4, IL-5, IL-10, and IL-13 mRNA by transgenic thymocytes is impaired relative to that in wild-type controls, while the expression of IL-6 and IFN-{gamma} mRNA is comparable (Fig. 2A). Transgenic splenocytes showed reduced expression of IL-4 and IL-5 and enhanced expression of IL-2 (Fig. 2A). The RPA was repeated with RNA prepared from FVB-lck line 4 animals, and similar results were obtained (data not shown). http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12594265 http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12594265 http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#_4 http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM http://purl.org/dc/terms/created 2014-07-03T14:31:59.150+02:00 http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZbMIl6afWD2FJ_a1NFMbNeSbDR3bwRh_S3_8HWczYIM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234