http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#head http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw http://www.nanopub.org/nschema#hasAssertion http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#assertion http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw http://www.nanopub.org/nschema#hasProvenance http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#provenance http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw http://www.nanopub.org/nschema#hasPublicationInfo http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#publicationInfo http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#assertion http://bio2rdf.org/drugbank:DB00242 http://bio2rdf.org/drugbank_vocabulary:ddi-interactor-in http://bio2rdf.org/drugbank_resource:DB00242_DB01656 http://bio2rdf.org/drugbank:DB01656 http://bio2rdf.org/drugbank_vocabulary:ddi-interactor-in http://bio2rdf.org/drugbank_resource:DB00242_DB01656 http://bio2rdf.org/drugbank_resource:DB00242_DB01656 http://purl.org/dc/terms/identifier drugbank_resource:DB00242_DB01656 http://bio2rdf.org/drugbank_resource:DB00242_DB01656 http://purl.org/dc/terms/title DDI between Cladribine and Roflumilast - Roflumilast may enhance the immunosuppressive effect of immunosuppressants such as cladribine. The Canadian roflumilast product monograph recommends avoiding concurrent use of roflumilast with any immunosuppressant medications due to the antiinflammatory/immune altering effects of roflumilast and the lack of relevant clinical experience with such use. Of note, this recommendation to avoid concurrent use does not apply to either inhaled corticosteroids (which have much more limited systemic immune-suppressing actions) or short-term systemic corticosteroid use. U.S. prescribing information does not contain this warning; but it appears prudent to avoid this combination when possible. http://bio2rdf.org/drugbank_resource:DB00242_DB01656 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://bio2rdf.org/drugbank_vocabulary:Drug-Drug-Interaction http://bio2rdf.org/drugbank_resource:DB00242_DB01656 http://www.w3.org/2000/01/rdf-schema#label DDI between Cladribine and Roflumilast - Roflumilast may enhance the immunosuppressive effect of immunosuppressants such as cladribine. The Canadian roflumilast product monograph recommends avoiding concurrent use of roflumilast with any immunosuppressant medications due to the antiinflammatory/immune altering effects of roflumilast and the lack of relevant clinical experience with such use. Of note, this recommendation to avoid concurrent use does not apply to either inhaled corticosteroids (which have much more limited systemic immune-suppressing actions) or short-term systemic corticosteroid use. U.S. prescribing information does not contain this warning; but it appears prudent to avoid this combination when possible. [drugbank_resource:DB00242_DB01656] http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#provenance http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#assertion http://semanticscience.org/resource/SIO_000253 http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3 http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#publicationInfo http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#signature.MCwCFFG_4BTkPCvG http://purl.org/nanopub/x/hasPublicKey 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 http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#signature.MCwCFFG_4BTkPCvG http://purl.org/nanopub/x/hasSignature MCwCFFG/4BTkPCvGhD+uwIkQKTYmFr4aAhQct9aUVlWXS+kqXMsmTrJ0bTaXTg== http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#signature.MCwCFFG_4BTkPCvG http://purl.org/nanopub/x/signedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw http://purl.org/dc/terms/created 2018-03-30T11:12:28.708+02:00 http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw http://purl.org/dc/terms/license https://creativecommons.org/licenses/by-nc/4.0/ http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw http://purl.org/nanopub/x/hasSignatureElement http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw#signature.MCwCFFG_4BTkPCvG http://bio2rdf.org/drugbank_resource:DB00242_DB01656_nanopub.RAZVYDJy4pw6h03efp22CuiYTBT0i7quBjTLisu5JWFDw http://www.w3.org/ns/prov#wasGeneratedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.3c184e6c-ceb8-4275-a679-71dfbdac2a11 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#specializationOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.3c184e6c-ceb8-4275-a679-71dfbdac2a11 http://purl.org/dc/terms/identifier 3c184e6c-ceb8-4275-a679-71dfbdac2a11 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.3c184e6c-ceb8-4275-a679-71dfbdac2a11 http://www.w3.org/ns/prov#used https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.3c184e6c-ceb8-4275-a679-71dfbdac2a11 http://www.w3.org/ns/prov#wasAssociatedWith https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.3c184e6c-ceb8-4275-a679-71dfbdac2a11 http://www.w3.org/ns/prov#wasStartedBy http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/dc/terms/isVersionOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/pav/version eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234