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p(MGI:Nfib) -| (tscript(p(MGI:Mtf1)) -> r(MGI:Mt1))
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tscript(p(MGI:Mtf1)) -> r(MGI:Mt1)
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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unlike other target genes of NFI, direct interaction of NFI with MT-I promoter is not necessary to mediate its repression. an NFI-C deletion mutant lacking the DNA binding domain continued to repress MT-I promoter. Overexpression of MTF-1, the key trails-acting factor involved in MT-I gene transcription, surmounted NFI-mediated repression of the basal and zinc-induced MT-I promoter activity. Interaction of NFI with another protein(s), probably MTF-I, may be involved in this repression.
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Selventa
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2014-07-03T14:31:42.545+02:00
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