@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAZIrSYs7cl7zFLzjkOajXb5jkmTTk7bd07kBrS1D6Qgc> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAZIrSYs7cl7zFLzjkOajXb5jkmTTk7bd07kBrS1D6Qgc#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:9588;
    a Protein: .
  
  sub:_2 occursIn: obo:EFO_0002795, obo:UBERON_0004852, species:9606;
    rdf:object go:0001525;
    rdf:predicate belv:decreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:PTEN) -| bp(GOBP:angiogenesis)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "Very recent studies have suggested possible connections between Akt, PTEN, and integrin biology. For example, integrin- airlinked kinase (ILK) activation is inhibited by blockade of Akt function (Persad et al., 2000), and PTEN interacts with focal adhesion kinase (FAK) and influences cell migration (Tamura et al., 1999). These interactions affect cell survival, an event influenced by both VEGF and integrins. Also, cell migration and angiogenesis are reg- ulated by Akt and PTEN, and these cellular responses are clearly mediated by integrins (Jiang et al., 2000). By overexpression approaches, we have directly impli- cated Akt and PTEN in the pathway from VEGF to integ- rin activation. Thus, some of the functions of PI 3-kinase, Akt, and PTEN in cell migration may depend upon their role in integrin activation, and engagement of VEGFR2";
    prov:wasQuotedFrom pubmed:11090623 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:11090623;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:31:38.213+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}