. . . . . . . . . . . . . "path(SDIS:\"high-fat diet\") -| r(MGI:Apoe)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Therefore, we examined the expression of several genes important in lipid metabolism in ATMs from normal diet and high-fat diet mice. Apoe was downregulated in ATMs with high-fat diet. Expression of both adipocyte differentiation–related protein (Adfp) and peroxisome proliferator activation receptor-? (Pparg) were increased in high-fat diet ATMs (Fig. 4A). To determine the functional significance of these findings, we examined the lipid content of ATMs isolated from normal diet–and high-fat diet–fed animals by Nile Red staining. Both macrophage (CD11b+) and nonmacrophage (CD11b?) cells in SVF cultures had Nile Red–positive vesicles; however, ATMs had more pronounced lipid accumulation, especially in obese mice " . . "Selventa" . . . . "2014-07-03T14:33:07.734+02:00"^^ . . .