http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#Head http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#assertion http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#provenance http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#assertion http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:106675 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D008099 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-diseases/cancer http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_1 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Adipoq) -| path(SDIS:cancer) http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_3 http://www.w3.org/ns/prov#value The aim of this study was to examine the effects of adiponectin on the progression of NASH to cirrhosis and tumor formation using adiponectin-knockout (KO) mice. METHODS: Using a choline-deficient L-amino acid-defined (CDAA) diet-induced mouse NASH model, liver histology and oxidative stress markers were investigated in KO and wild-type (WT) mice. RESULTS: Hepatic steatosis was enhanced to a greater extent in KO mice, compared to WT mice after a 1-week CDAA diet. After 24 weeks, 6 out of 14 KO mice developed liver cirrhosis and hepatic tumors, whereas the 15 WT mice showed only simple steatosis. In KO mice, hepatic cytochrome P450 2E1 levels were upregulated, and markers of oxidative stress (thiobarbituric acid reactive substances, 8-hydroxydeoxyguanosine-positive cells) were significantly increased compared with WT mice. http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17459514 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17459514 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#_3 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk http://purl.org/dc/terms/created 2014-07-03T14:30:50.450+02:00 http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYyGZ71zqKBn4RgPet8ETbfQ2NpcSzLNYIe3P62yPDsk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234