. . . . . . . . . . . . "[In the light of present understanding, the factors linking HPV to cervical squamous cell carcinogenesis can be summarized as follows: (1) HPV infection in the uterine cervix is a sexually transmitted disease; (2) HPV lesions in the uterine cervix seem to be equivalent to CIN in their clinical behavior, i.e., possess the potential to progress towards CIS; (3) malignant transformation seems to depend on HPV type, being conditioned by integration of HPV DNA with the host cell DNA; (4) malignant transformation most probably requires synergistic effects between the virus and chemical or physical carcinogens, or other infectious agents; (5) genetic disposition (data available on animals only) significantly contributes to the process]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2016-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2016-05-13T12:51:35+02:00"^^ . . . . . . . . . . . "v4.0.0.0" . "v4.0.0" .