sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "We now show for the first time that suppression of T-bet ameliorates EAE by limiting the differentiation of autoreactive Th1 cells, as well as inhibiting pathogenic Th17 cells via regulation of IL-23R. (from text:) We consistently found that the number of Th17 cells in the CNS of EAE-affected mice was highest at the acute phase of disease as shown in Fig. 4 and decreased over time as shown in Fig. 5. However, the number of Th17 cells in the CNS was usually undetectable in the siRNA-T-bet-treated mice at all time points." ;
    prov:wasQuotedFrom pubmed:17237380 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:17237380 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}