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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#_4 http://www.w3.org/ns/prov#value Classically the insulin receptor substrate-1 (IRS-1) is an essential component of insulin-like growth factor type 1 receptor (IGF-IR) signalling, providing an interface between the receptor and key downstream signalling cascades. Here, however, we show that in tamoxifen-resistant MCF-7 (Tam-R) breast cancer cells, that are highly dependent on epidermal growth factor receptor (EGFR) for growth, IRS-1 can interact with EGFR and be preferentially phosphorylated on tyrosine (Y) 896, a Grb2 binding site. http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17902048 http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17902048 http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#_4 http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc http://purl.org/dc/terms/created 2014-07-03T14:33:12.598+02:00 http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYa_KWwCRufqs5aOrE1qwBTlr3RuMYNohAmdbwoVzwNc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234