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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAY_WfcuPahjXXYjAcdoW1wfaBPdkWQaF_pUB15jAEw_0#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAY_WfcuPahjXXYjAcdoW1wfaBPdkWQaF_pUB15jAEw_0#_6 http://www.w3.org/ns/prov#value While the activity of these enzymes in the newborn PEX2-/- mouse liver was normal, all enzyme activities were significantly elevated in the postnatal knockout mouse livers (Fig. 1A to D). The pattern observed in PEX2 knockout mice differed markedly, with enzyme activity continuing to increase in postnatal PEX2-/- mice. For example, HMG-CoA reductase {HMGCR} activity was increased 5-fold at P3-5 and 10-fold at P7-10 in knockout mice (Fig. 1A). Activities of IPP isomerase, {IDI1} FPP synthase {FDPS}, and squalene synthase {FDFT1} were increased twofold at P3-5 in PEX2-/- mice (Fig. 1B to D). 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