http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.Head http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://www.nanopub.org/nschema#hasAssertion http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://www.nanopub.org/nschema#hasProvenance http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.provenance http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://www.nanopub.org/nschema#hasPublicationInfo http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.pubinfo http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._1 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._2 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._1 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._3 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._1 http://www.w3.org/2000/01/rdf-schema#comment A decreased interaction with HDAC1 and deacetylation of SP3. Increase of about 4.5% of activity of the TERT promoter. Decreased recruitment of HDAC1 and increased binding of RNA polymerase II with promoter DNA. http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._2 http://semanticscience.org/resource/SIO_000300 551 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._3 http://semanticscience.org/resource/SIO_000300 551 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._4 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._5 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._4 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._6 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._4 http://www.w3.org/2000/01/rdf-schema#comment Great loss of sumoylation, 20-fold increase in transcriptional activity and diffuse nuclear localization. Further small increase in transcriptional activity; when associated with R-120. Increased interaction with HDAC1 and deacetylation of SP3. About 50% decrease in activity of the TERT promoter. Enhances recruitment of HDAC1 and inhibits binding of RNA polymerase II with promoter DNA. http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._5 http://semanticscience.org/resource/SIO_000300 551 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._6 http://semanticscience.org/resource/SIO_000300 551 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.w3.org/2000/01/rdf-schema#comment Mutagenesis site occurs in NX_Q02447-1 at amino acids 551 - 551. http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.seqFeature http://purl.obolibrary.org/obo/#BFO_0000066 http://www.nextprot.org/db/search#NX_Q02447-1 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._1 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._4 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.seqFeature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_000010 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.provenance http://www.nextprot.org/help/quality_criteria/gold http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000205 http://www.nextprot.org/help/quality_criteria/gold http://www.w3.org/2000/01/rdf-schema#label neXtProt gold http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._10 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000218 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000218 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._9 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://purl.org/net/provenance/ns#usedData http://www.ebi.ac.uk/QuickGO/GProtein?ac=Q02447 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://purl.org/net/provenance/ns#usedData http://www.geneontology.org/cgi-bin/references.cgi#GO_REF:0000019 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://purl.org/net/provenance/ns#usedData http://www.uniprot.org/uniprot/Q02447 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://purl.org/ontology/wi/core#evidence http://www.nextprot.org/help/quality_criteria/gold http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000006 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000200 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._7 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._9 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.w3.org/ns/prov#wasGeneratedBy http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._10 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion http://www.w3.org/ns/prov#wasGeneratedBy http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._8 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.pubinfo http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://purl.org/dc/terms/created 2014-09-19T00:00:00.0Z http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://purl.org/dc/terms/rights http://creativecommons.org/licenses/by/3.0/ http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://purl.org/dc/terms/rightsHolder http://nextprot.org http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://purl.org/net/provenance/ns#usedData neXtProt database http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://swan.mindinformatics.org/ontologies/1.2/pav/authoredBy CALIPHO project http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://swan.mindinformatics.org/ontologies/1.2/pav/authoredBy http://orcid.org/0000-0001-6710-1373 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://swan.mindinformatics.org/ontologies/1.2/pav/authoredBy http://orcid.org/0000-0001-6818-334X http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://swan.mindinformatics.org/ontologies/1.2/pav/authoredBy http://orcid.org/0000-0002-1303-2189 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://swan.mindinformatics.org/ontologies/1.2/pav/authoredBy http://orcid.org/0000-0003-1813-6857 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://swan.mindinformatics.org/ontologies/1.2/pav/versionNumber 3 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://www.w3.org/ns/prov#wasGeneratedBy http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._11 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU http://www.w3.org/ns/prov#wasGeneratedBy http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._12 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._11 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000248 http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._12 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000248