. . . . . . . . "A decreased interaction with HDAC1 and deacetylation of SP3. Increase of about 4.5% of activity of the TERT promoter. Decreased recruitment of HDAC1 and increased binding of RNA polymerase II with promoter DNA." . "551"^^ . . "551"^^ . . . . . . "Great loss of sumoylation, 20-fold increase in transcriptional activity and diffuse nuclear localization. Further small increase in transcriptional activity; when associated with R-120. Increased interaction with HDAC1 and deacetylation of SP3. About 50% decrease in activity of the TERT promoter. Enhances recruitment of HDAC1 and inhibits binding of RNA polymerase II with promoter DNA." . "551"^^ . . "551"^^ . . "Mutagenesis site occurs in NX_Q02447-1 at amino acids 551 - 551." . . . . . . "neXtProt gold" . . . . . . . . . . . . . . . "2014-09-19T00:00:00.0Z"^^ . . . "neXtProt database" . "CALIPHO project" . . . . . "3" . . . . .