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Increase of about 4.5% of activity of the TERT promoter. Decreased recruitment of HDAC1 and increased binding of RNA polymerase II with promoter DNA." } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._2", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "551" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._3", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "551" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._4", "@type" : [ "http://purl.org/obo/owl/SO#SO_0001148", "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition" ], "http://semanticscience.org/resource/SIO_000053" : [ { "@id" : "http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._5" }, { "@id" : "http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._6" } ], "http://www.w3.org/2000/01/rdf-schema#comment" : [ { "@value" : "Great loss of sumoylation, 20-fold increase in transcriptional activity and diffuse nuclear localization. Further small increase in transcriptional activity; when associated with R-120. Increased interaction with HDAC1 and deacetylation of SP3. About 50% decrease in activity of the TERT promoter. Enhances recruitment of HDAC1 and inhibits binding of RNA polymerase II with promoter DNA." } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._5", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "551" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU._6", "@type" : [ "http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition" ], "http://semanticscience.org/resource/SIO_000300" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#integer", "@value" : "551" } ] }, { "@id" : "http://www.nextprot.org/nanopubs#NX_Q02447-1_MUTAGEN_551_551.RAYTlJvHXZksfssfRHp29ZCN0ROM05stdLs_BqFlS6NOU.assertion", "http://www.w3.org/2000/01/rdf-schema#comment" : [ { "@value" : "Mutagenesis site occurs in NX_Q02447-1 at amino acids 551 - 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