http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#Head http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#assertion http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#provenance http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#assertion http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3560 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000115 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0000014 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_1 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0001302 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GOBP:"replicative cell aging") -> p(HGNC:FABP5) http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_3 http://www.w3.org/ns/prov#value Aging is associated with the progressive pathophysiologic modification of endothelial cells. In vitro endothelial cell senescence is accompanied by proliferative activity failure and by perturbations in gene and protein expressions. Moreover, this cellular senescence in culture has been proposed to reflect processes that occur in aging organisms. In order to observe the changing patterns of protein expression in senescent human dermal microvascular endothelial cells (HDMECs), proteins obtained from both early- and late-passaged HDMECs were separated by two-dimensional electrophoresis, visualized by silver staining, and quantified by image processing. Proteins of interest were extracted by in-gel digestion with trypsin and quantified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), by searching the National Center for Biotechnology Information protein-sequence database. More than 2000 spots were detected by 2D electrophoresis within a linear pH range of 3-10. Twenty-two major differentially expressed spots were observed in serially passaged HDMECs and identified with high confidence by MALDI-TOF-MS. One of these spots was found to be a 14-15 kDa psoriasis-associated fatty acid-binding protein (PA-FABP) with high affinity for long-chain fatty acids. The expression of PA-FABP was confirmed to be elevated in senescent HDMECs (passage 20) by fluorescence-activated cell sorting (FACS), confocal laser microscopy, and by immunohistochemistry in aged human skin tissue. Our results suggest that the overexpression of FABP in cultured senescent HDMECs is closely related to skin aging. http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15335354 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15335354 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#_3 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac http://purl.org/dc/terms/created 2014-07-03T14:32:28.486+02:00 http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYDwppfLjHfLD1hFfgW7xy1JQAq5MdrrXM2Re8LFswac http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234