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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#_4 http://www.w3.org/ns/prov#value The effect of OPC3911 on cAMP-PK activity ratios at different levels of lipolysis achieved by noradrenaline stimulation revealed that the reduction of cAMP-PK caused by 1 nM insulin was completely blocked by 3 microM OPC3911. The effect of OPC3911 was not due to an excessive increase in cellular cAMP resulting in 'supramaximal' lipolysis unresponsive to insulin. These data demonstrate that reduction in cAMP levels by the activation of cGI-PDE may be sufficient to account for the antilipolytic action of insulin. http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/7718614 http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/7718614 http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#_4 http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI http://purl.org/dc/terms/created 2014-07-03T14:33:46.891+02:00 http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYBbNuTm_td6_QYIeNL239_KrtLJRwqjSYdj35lDY-NI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234