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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#_5 http://www.w3.org/ns/prov#value A cultured myocardial cell model was used to examine the role of protein kinase C-dependent pathways in the transcriptional activation of two cardiac muscle genes [myosin light chain 2 (MLC-2) and atrial natriuretic factor (ANF)] during alpha-adrenergic receptor-mediated hypertrophy. Phorbol ester (phorbol 12-myristate 13-acetate) and the alpha-adrenergic agonist phenylephrine both activate protein kinase C (PKC) and induce 4- to 5-fold increases in the expression of MLC-2 and ANF promoter/luciferase reporter genes with little effect on Rous sarcoma virus/luciferase or minimal prolactin promoter/luciferase genes. http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/1531537 http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/1531537 http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#_5 http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18#pubinfo http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18 http://purl.org/dc/terms/created 2014-07-03T14:32:27.713+02:00 http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAY51jQIPRJOqbI6oUR3EiSK16XXySzqEQXHvu6WkRt18 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234