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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#_3 http://www.w3.org/ns/prov#value Peripheral blood mononuclear cells of patients with COPD have decreased telomere length, a hallmark of senescing cells in vitro, when compared with normal individuals (225). This observation has been extended to lung cells, as alveolar epithelial and endothelial cells of emphysema patients exhibited enhanced expression of markers of cell senescence including p16Ink4a and p21CIP1/WAF1/Sdi1 and telomere shortening when compared with smokers without emphysema and normal individuals (320).TGF-beta1 played a role in the upregulation of p21CIP1/WAF1/Sdi1 in the alveolar type II-like epithelial cell line A549 (205). http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17615396 http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17615396 http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#_3 http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus#pubinfo http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus http://purl.org/dc/terms/created 2014-07-03T14:33:11.686+02:00 http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAY2L7MxIgfUSUU-az89-z0W_ZKe4pwZ93dGQcEOCefus http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234