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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#_4 http://www.w3.org/ns/prov#value By substituting these tyrosine residues in LAT with phenylalanine and by utilizing phosphorylated peptides derived from these sites, we mapped the tyrosine residues in LAT required for the direct interaction and activation of Vav, p85/p110alpha and phospholipase Cgamma1 (PLCgamma1). Our results indicate that Tyr(226) and Tyr(191) are required for Vav binding, whereas Tyr(171) and Tyr(132) are necessary for association and activation of phosphoinositide 3-kinase activity and PLCgamma1 respectively. http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11368773 http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11368773 http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#_4 http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY http://purl.org/dc/terms/created 2014-07-03T14:31:41.806+02:00 http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAXvxU32-yMXXq0YV2jQw_cYhGYK2E38L0n9JT72GTFUY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234