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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#_5 http://www.w3.org/ns/prov#value Here, we determine that dHAND also interacts with the myocyte enhancer binding factor-2c (MEF2C) protein, which belongs to MADS-box transcription factors and is essential for heart development. dHAND and MEF2C synergistically activated expression of the atrial naturetic peptide gene (ANP) in transfected HeLa cells. GST-pulldown and immunoprecipitation assay demonstrate that full-length MEF2C protein is able to interact with dHAND in vitro and in vivo, just like MEF2A and bHLH transcription factors MyoD in skeletal muscle cells. In addition, electrophoretic mobility shift assays (EMSAs) demonstrate that MEF2C and dHAND do not influence each other's DNA binding activity. Using chromatin immunoprecipitation (ChIP) analysis in H9c2 cells we show that dHAND interact with MEF2C to form protein complex and bind A/T sequence in promoter of ANP. http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15486975 http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15486975 http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#_5 http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E#pubinfo http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E http://purl.org/dc/terms/created 2014-07-03T14:32:33.493+02:00 http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAXmCqYhIfCYPdgDJlSFBeH9cpKYKEaombzymXT1-Xs1E http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234