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[However, the similarity between the distal colonic aganglionosis in Hirschsprung disease and that due to EDN3 or EDNRB mutations led to the hypothesis that levels of expression of these genes might be affected in the absence of mutation, thus causing the Hirschsprung disease phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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