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kin(complex(SCOMP:"p85/p110 PI3Kinase Complex")) -> p(HGNC:AKT1,pmod(P,S,473))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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Akt activation is dependent on its phosphorylation at Thr308 and Ser473. The mechanism by which thrombin induces Akt phosphorylation is controversial, as is the role of Akt in platelet function.Platelet PAR stimulation causes rapid Akt phosphorylation downstream of PLC; while in the continuous stimulation, ADP and PI3K are required for maintaining Akt phosphorylation.
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