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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_7 http://www.w3.org/ns/prov#value More importantly, we demonstrate that Gq/11 proteins interact with KDR in vivo, and the interaction of Gq/11 proteins with KDR does not require KDR tyrosine phosphorylation. Surprisingly, the Gq/11 antisense oligonucleotide completely inhibits VPF/VEGF-stimulated KDR phosphorylation. Expression of a constitutively active mutant of G11 but not Gq can cause phosphorylation of KDR and MAPK. In addition, a Gbetagamma minigene, hbetaARK1(495), inhibits VPF/VEGF-stimulated HUVEC proliferation, MAPK phosphorylation, and intracellular Ca2+ mobilization but has no effect on KDR phosphorylation. Taken together, this study demonstrates that Gq/11 proteins mediate KDR tyrosine phosphorylation and KDR-mediated HUVEC proliferation through interaction with KDR. http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12670961 http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12670961 http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_7 http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4 http://purl.org/dc/terms/created 2014-07-03T14:32:00.720+02:00 http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234