[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_1", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0043234" ], "http://purl.obolibrary.org/obo/BFO_0000051" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_2" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_3" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4379" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_3", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6307" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_4", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0016301" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_5" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_5", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6307" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_6", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://purl.obolibrary.org/obo/EFO_0002795" }, { "@id" : "http://purl.obolibrary.org/obo/UBERON_0004852" }, { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_4" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/directlyIncreases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "complex(p(HGNC:GNA11),p(HGNC:KDR)) => kin(p(HGNC:KDR))" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_8" } ], "http://purl.org/pav/version" : [ { "@value" : "20131211" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_7", "http://www.w3.org/ns/prov#value" : [ { "@value" : "More importantly, we demonstrate that Gq/11 proteins interact with KDR in vivo, and the interaction of Gq/11 proteins with KDR does not require KDR tyrosine phosphorylation. Surprisingly, the Gq/11 antisense oligonucleotide completely inhibits VPF/VEGF-stimulated KDR phosphorylation. Expression of a constitutively active mutant of G11 but not Gq can cause phosphorylation of KDR and MAPK. In addition, a Gbetagamma minigene, hbetaARK1(495), inhibits VPF/VEGF-stimulated HUVEC proliferation, MAPK phosphorylation, and intracellular Ca2+ mobilization but has no effect on KDR phosphorylation. Taken together, this study demonstrates that Gq/11 proteins mediate KDR tyrosine phosphorylation and KDR-mediated HUVEC proliferation through interaction with KDR." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12670961" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_8", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12670961" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#_7" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:32:00.720+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAX_V8Zp4nxjn4q8wfxaC865GN1lneq8DvCzNZNrRs0D4#pubinfo" } ]