@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAXYaNsW040k-CW5CGxW_LQ3p0vP95iXfVjDZUfBamzHw> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAXYaNsW040k-CW5CGxW_LQ3p0vP95iXfVjDZUfBamzHw#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0042789 .
  
  sub:_2 geneProductOf: hgnc:11621;
    a Protein: .
  
  sub:_3 geneProductOf: hgnc:11028;
    a RNA: .
  
  sub:_4 occursIn: obo:CL_0000182, species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "tscript(p(HGNC:HNF1A)) => r(HGNC:SLC4A2)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_5 prov:value "Dual luciferase assay of PLC/PRF/5 cells transiently transfected with construct I-b1 mutated at the HNF1 site (construct I-b1[HNF1]mut; Figure 5) indicated that abrogation of the HNF1 element results in low promoter activity, with no response to the combination of UDCA and dexamethasone or to either of these compounds alone (Figure 11A). The fact that baseline transcriptional activity of construct I-b1[HNF1]mut was also markedly attenuated compared with that of the wild-type construct (4.5-fold; Figure 11A) suggested that an HNF1-bound transcription factor forms part of the baseline transcription machinery of AE2 {SLC4A2}alternate promoter in intact liver cells. ChIP assays against HNF1alpha in nuclear extracts from PLC/PRF/5 cells (with and without treatments) further supported such a view.";
    prov:wasQuotedFrom pubmed:18188457 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:18188457;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:14.448+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}