@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_head {
  this: np:hasAssertion dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_assertion;
    np:hasProvenance dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_provenance;
    np:hasPublicationInfo dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_assertion a np:Assertion .
  
  dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_provenance a np:Provenance .
  
  dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_assertion {
  miriam-gene:5563 a ncit:C16612 .
  
  lld:C0006826 a ncit:C7057 .
  
  dgn-gda:DGNa374bae7af00ddd9147627f9663fd5ea sio:SIO_000628 miriam-gene:5563, lld:C0006826;
    a sio:SIO_001121 .
}

dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_provenance {
  dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_assertion dcterms:description
      "[Using crude EVOO phenolic extracts highly enriched in the secoiridoids oleuropein aglycon and decarboxymethyl oleuropein aglycon, we show for the first time that (1) the anticancer activity of EVOO secoiridoids is related to the activation of anti-aging/cellular stress-like gene signatures, including endoplasmic reticulum (ER) stress and the unfolded protein response, spermidine and polyamine metabolism, sirtuin-1 (SIRT1) and NRF2 signaling; (2) EVOO secoiridoids activate AMPK and suppress crucial genes involved in the Warburg effect and the self-renewal capacity of `immortal` cancer stem cells; (3) EVOO secoiridoids prevent age-related changes in the cell size, morphological heterogeneity, arrayed cell arrangement and senescence-associated β-galactosidase staining of normal diploid human fibroblasts at the end of their proliferative lifespans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:23370395;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP161906.RAXT8JElwewo3J3TLFeSUkAWiP_-4ecLTRho3nvWid_GE130_publicationInfo {
  this: dcterms:created "2014-10-02T12:33:27+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
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    pav:version "v2.1.0.0" .
  
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