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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#_3 http://www.w3.org/ns/prov#value Interleukin-1beta (IL-1beta) is a proinflammatory cytokine that plays a central role in inflammatory bowel disease (IBD). In order to elucidate the mechanism of motility disorders frequently observed in IBD, we investigated the long term effects of IL-1beta on rat ileal smooth muscle contractility by using an organ culture system. When ileal smooth muscle strips were cultured with IL-1beta (10 ng/ml), contractions elicited by high K+ and carbachol were inhibited in a time-dependent manner. http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14512413 http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14512413 http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#_3 http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc http://purl.org/dc/terms/created 2014-07-03T14:32:09.463+02:00 http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAXR07MYuhNKCpQVUpMeIUSGlo2bpBZmTl2N51tnZ4XKc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234