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[Searching for animal models with altered levels of FXR, we found that long-lived Little mice have high levels of FXR and do not develop liver cancer with age and after DEN injections due to failure to activate gankyrin and eliminate Rb, p53, HNF4α and C/EBPα proteins.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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