http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_head http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_assertion http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_provenance http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_assertion http://identifiers.org/ncbigene/2477 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0004364 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/gene-disease-association.ttl#DGN44f52de1c7e59d660afa9021b6343c93 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/2477 http://rdf.disgenet.org/gene-disease-association.ttl#DGN44f52de1c7e59d660afa9021b6343c93 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0004364 http://rdf.disgenet.org/gene-disease-association.ttl#DGN44f52de1c7e59d660afa9021b6343c93 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_provenance http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_assertion http://purl.org/dc/terms/description [There are three presumable mechanisms involved in the development of POI, namely apoptosis acceleration, follicular maturation blocking and premature follicle activation, through the following studied causes: (i) chromosomal abnormalities or gene mutations: mostly involve X chromosome, such as FMR1 premutation; more and more potentially causal genes have been screened recently; (ii) metabolic disorders such as classic galactosaemia and 17-OH deficiency; (iii) autoimmune mediated ovarian damage: observed alone or with some certain autoimmune disorders and syndromes; but the specificity and sensitivity of antibodies towards ovary are still questionable; (iv) iatrogenic: radiotherapy or chemotherapy used in cancer treatment, as well as pelvic surgery with potential threat to ovaries' blood supply can directly damage ovarian function; (v) virus infection such as HIV and mumps; (vi) toxins and other environmental/lifestyle factors: cigarette smoking, toxins (e.g., 4-vinylcyclohexene diepoxide), and other environmental factors are associated with the development of POI.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/22932883 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/eco.owl#ECO_0000203 http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://purl.org/pav/2.0/importedOn 2014-02-25 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000212 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/dc/terms/created 2014-10-02T12:39:44+02:00 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v2.1.0/void.ttl#IBIGroup http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/pav/2.0/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP767486.RAXDmzsVH9jVyibfwwvsUpWaiCB6UIg8ZIO_5V4zBOUxc http://purl.org/pav/2.0/version v2.1.0.0 http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://purl.org/pav/2.0/version v2.1.0