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[Therefore, in Vil-Cre-HSD2(-/-) Apc(min/+) mice, epithelial cell 11?-HSD2 deficiency leads to inhibition of adenoma initiation and growth by attenuation of COX-2 expression, increased cell-cycle arrest, and inhibition of mTOR signaling as a result of increased tumor intracellular active glucocorticoids.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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