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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#_6 http://www.w3.org/ns/prov#value TOPK was shown to promote transformation in vitro and in vivo, and knockdown of TOPK in HCT116 colorectal cancer cells reduced this cell lines' tumorigenic properties in vitro and in vivo. Furthermore, a positive feedback loop between TOPK and ERK2 was identified. With epidermal growth factor treatment, knockdown of either TOPK or ERK2 in HCT116 cells resulted in a decreased phosphorylation of ERK2 or TOPK, respectively, and knockdown of TOPK in HCT116 colorectal cancer cells blocked the phosphorylation of downstream substrates of ERK2. CONCLUSIONS: The positive feedback loop between TOPK and ERK2 increases tumorigenesis properties of HCT116 colorectal cancer cells, and TOPK-regulated signaling may serve as a potential therapeutic target in colorectal cancer. http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17631144 http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17631144 http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#_6 http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU http://purl.org/dc/terms/created 2014-07-03T14:33:11.933+02:00 http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWZL2cf2nEc9gqXMcSMOnvVL8cOT6E2BOMazMyXq3pxU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234