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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#_6 http://www.w3.org/ns/prov#value Repair mechanisms activated by ROS-induced DNA damage require cell cycle arrest, which is mediated by several damage checkpoints (Abraham 2001). Following recognition of DNA damage by PARP-1, a simultaneous 9-1-1 ‘alert’ complex is formed, consisting of Rad9, Rad1 and Hus1, which are activated under the control of Rad17 to initiate a downstream DNA damage-signaling cascade (Figure 1) (Melo et al., 2001; Kondo et al., 2001). http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18208352 http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18208352 http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#_6 http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo http://purl.org/dc/terms/created 2014-07-03T14:33:15.863+02:00 http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWFrC68JizbwgwdLSYdNTE7L5rT1G3v1VA6O6PsbNDBo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234