http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#Head http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#assertion http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#provenance http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#assertion http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5464 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_3 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_4 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3467 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_3 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_2 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://disease-ontology.org/term/DOID:3620 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_5 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_1 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#assertion http://www.w3.org/2000/01/rdf-schema#label kin(complex(SCOMP:"p85/p110 PI3Kinase Complex")) -> (p(HGNC:IGF1) -| tscript(p(HGNC:ESR1))) http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:IGF1) -| tscript(p(HGNC:ESR1)) http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_7 http://www.w3.org/ns/prov#value IGF-I decreased ERalpha activity in the presence of estradiol, and this effect was mediated by PI3K. We also observed a regulated interaction between beta-catenin, one of the main GSK3 nuclear targets, and ERalpha. Transfection with a nondegradable mutant of beta-catenin blocked the increase in ERalpha transcriptional activity induced by the PI3K inhibitor wortmannin, suggesting a role for beta-catenin in estrogen signaling. http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16497810 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16497810 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#_7 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ http://purl.org/dc/terms/created 2014-07-03T14:32:56.511+02:00 http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAWCkm5EQS7mIrGXbj5mV9WUGKbYXoKCLQX3V9GKElQmQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234