@prefix this: . @prefix rdfs: . @prefix xsd: . @prefix sio: . @prefix ncit: . @prefix lld: . @prefix miriam-gene: . @prefix miriam-pubmed: . @prefix eco: . @prefix wi: . @prefix prov: . @prefix pav: . @prefix prv: . @prefix dcterms: . @prefix np: . @prefix dgn-np: . @prefix dgn-gda: . @prefix dgn-void: . dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_head { this: np:hasAssertion dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_assertion; np:hasProvenance dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_provenance; np:hasPublicationInfo dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_publicationInfo; a np:Nanopublication . dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_assertion a np:Assertion . dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_provenance a np:Provenance . dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_publicationInfo a np:PublicationInfo . } dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_assertion { miriam-gene:9560 a ncit:C16612 . lld:C0023493 a ncit:C7057 . dgn-gda:DGNfda184936ed567883e1f354ba57529f0 sio:SIO_000628 miriam-gene:9560, lld:C0023493; a sio:SIO_001121 . } dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_provenance { dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_assertion dcterms:description "[We studied mechanisms of extravasation of leukemic cells using adult T cell leukemia (ATL) cells and report the following novel features of cell surface heparan sulfate proteoglycan on ATL cells in ATL cell adhesion to endothelium: ATL cells adhere to endothelial cells through already activated integrins without exogenous stimulation; different from any other hematopoietic cells, ATL cells express a characteristic heparan sulfate capable of immobilizing heparin-binding chemokine macrophage inflammatory protein (MIP)-1 beta, a potent T cell integrin trigger, produced by the cells themselves; competitive interruption of endogenous heparan sulfate proteoglycan synthesis reduces cell surface MIP-1 beta and prevents ATL cells from integrin-mediated adhesion to endothelial cells or intercellular adhesion molecule-1 triggered through G-protein.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en; wi:evidence dgn-void:source_evidence_literature; sio:SIO_000772 miriam-pubmed:8920885; prov:wasDerivedFrom dgn-void:befree-20150227; prov:wasGeneratedBy eco:ECO_0000203 . dgn-void:befree-20150227 pav:importedOn "2015-02-27"^^xsd:date . dgn-void:source_evidence_literature a eco:ECO_0000212; rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en; rdfs:label "DisGeNET evidence - LITERATURE"@en . } dgn-np:NP826278.RAW8xY-VJoy7_msXx1bxLQ6hbr7P5OTT0xWGBhjXmFuWM130_publicationInfo { this: dcterms:created "2015-08-25T14:46:01+02:00"^^xsd:dateTime; dcterms:rights ; dcterms:rightsHolder dgn-void:IBIGroup; dcterms:subject sio:SIO_000983; prv:usedData dgn-void:disgenetv3.0rdf; pav:authoredBy , , , , ; pav:createdBy ; pav:version "v3.0.0.0" . dgn-void:disgenetv3.0rdf pav:version "v3.0.0" . }