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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#_5 http://www.w3.org/ns/prov#value SDF1alpha resulted in rapid activation of the extracellular signal-regulated kinase (ERK)1/2. This SDF1alpha-induced ERK activity was dose dependent and could be inhibited by pre-treatment of the cells with either pertussis toxin, an inactivator of G-protein-coupled receptors, or PD98059, a MEK1 inhibitor. Concomitant with ERK activation, SDF1alpha also activated the downstream transcription factor Ets, a substrate for ERK phosphorylation. Further, downstream activation of genes associated with cell survival, differentiation and migration was assessed using a G-protein-coupled receptor pathway-focused microarray. We found that 23 genes, including PDK1, Egr-1, Grm5, and E-selectin, were up-regulated by SDF1alpha. http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15816868 http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15816868 http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#_5 http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU http://purl.org/dc/terms/created 2014-07-03T14:32:42.539+02:00 http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAW4HjC-x1vtROis7nD8NHmtBtipL1qmuit5Cd3LjdaUU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234