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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#_3 http://www.w3.org/ns/prov#value Results show that acute hyperglycaemia induces an up-regulation of seven major genes, four of which were not previously reported in the literature. Northern blot analyses, performed on these 4 genes, confirm macroarrays results for alphav, beta4, c-myc, and MUC18. Moreover, time course analysis (0, 2, 4, 8, 2, 16, 24 h) of alphav, beta4 c-myc, and MUC18 mRNA expression, observed by northern blot assays, showed a peak at time points situated between 2 to 8 h. The 3 other genes (ICAM-1, beta1, and IL-8), were shown by others to be significantly upregulated after glucose stimulation. http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11848444 http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11848444 http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#_3 http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk http://purl.org/dc/terms/created 2014-07-03T14:31:46.988+02:00 http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAW2P2CbNpneHXWILtIbfZAGkvSmggsO2GPjDZcjFmJDk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234