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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVuojIljPTnnyE9ylrMWbMrxPixErSf89HY6R3QGx5f8#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAVuojIljPTnnyE9ylrMWbMrxPixErSf89HY6R3QGx5f8#_3 http://www.w3.org/ns/prov#value Nicotine or NNK (100 nM) increased proliferation ~2-fold in both cell lines. Immunoblotting analysis revealed that after daily administration of nicotine or NNK, Akt activation increased 41.5- fold in both cell lines. The reasons for the less robust increase in Akt activation on day 3 is unclear, but might be related to the higher dose (10 mM) or longer time course (5 days) used in Figure 4A. 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