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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#_6 http://www.w3.org/ns/prov#value Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes. Members of two families of CDK inhibitors, p16/p18 and p21/p27, become physically associated with and inhibit the activity of CDKs in response to a variety of growth-modulating signals. Here, we show that the representative members of both families of CDK inhibitors, p21waf1,cip1, p27kip1, and p18, can prevent the phosphorylation of their CDK partners, CDK2 and CDK6, by CDK-activating kinase. http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/7629134 http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/7629134 http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#_6 http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8 http://purl.org/dc/terms/created 2014-07-03T14:30:56.356+02:00 http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234