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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVpEhXLU8_82GGDdCpWJDneQ6yxVOQZ6asSaDsQl-Q1s#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAVpEhXLU8_82GGDdCpWJDneQ6yxVOQZ6asSaDsQl-Q1s#_2 http://www.w3.org/ns/prov#value To induce angiogenesis, growth factors need the proteolytically active uPA bound to uPAR [158, 159]. Urokinase can mediate the angiogenic effect of some growth factors not only by the localization of cell surface proteolysis but also by non-proteolytic mechanisms [160]. A fusion protein consisting of the amino terminal fragment of urokinase and of human serum albumin inhibits endothelial cell in vitro migration induced by bFGF and by VEGF [161], whereas a fusion protein consisting of the mouse uPA GFD and of the Fc-fragment of IgG inhibits bFGF and VEGF-stimulated branching morphogenesis in an endothelial cell tube formation assay on a fibrin matrix [162]. Retinoids stimulate endothelial cell tube formation also on fibrin matrices and addition of uPA to this system enhances this stimulation, whereas an antibody that blocked urokinase binding to the receptor inhibits the effects of uPA. 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