sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_3 ;
    pav:version "20131211" .
  sub:_2 prov:value "To induce angiogenesis, growth factors need the proteolytically active uPA bound to uPAR [158, 159]. Urokinase can mediate the angiogenic effect of some growth factors not only by the localization of cell surface proteolysis but also by non-proteolytic mechanisms [160]. A fusion protein consisting of the amino terminal fragment of urokinase and of human serum albumin inhibits endothelial cell in vitro migration induced by bFGF and by VEGF [161], whereas a fusion protein consisting of the mouse uPA GFD and of the Fc-fragment of IgG inhibits bFGF and VEGF-stimulated branching morphogenesis in an endothelial cell tube formation assay on a fibrin matrix [162].  Retinoids stimulate endothelial cell tube formation also on fibrin matrices and addition of uPA to this system enhances this stimulation, whereas an antibody that blocked urokinase binding to the receptor inhibits the effects of uPA. In the same system, steroid hormones (testosterone, dexamethasone) inhibit tube formation and addition of uPA to the system prevents the effect of steroids [163]." ;
    prov:wasQuotedFrom pubmed:11841347 .
  sub:_3 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11841347 ;
    prov:wasDerivedFrom beldoc: , sub:_2 .
}