http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#head http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#assertion http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#provenance http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#assertion http://rdf.disgenet.org/resource/gda/DGN3025ebd0941990b8c43adabc51b925a1 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/23277 http://rdf.disgenet.org/resource/gda/DGN3025ebd0941990b8c43adabc51b925a1 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0600139 http://rdf.disgenet.org/resource/gda/DGN3025ebd0941990b8c43adabc51b925a1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#provenance http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#assertion http://purl.org/dc/terms/description [Our experimental evidences show that: a) CLU 1 is the most abundant transcript variant. b) CLU 2 is expressed at a low level in normal fibroblasts and virtually absent in prostate cancer cells. c) CLU 1, and to a greater extent CLU 2 expression, increased by AZDC-TSA treatment in prostate cancer cells. d) Both CLU 1 and CLU 2 encode for secreted CLU. e) P2, a novel promoter that overlaps the CLU 2 Transcription Start Site (TSS), drives CLU 2 expression. f) A CpG island, methylated in prostate cancer cells and not in normal fibroblasts, is responsible for long-term heritable regulation of CLU 1 expression. g) ChIP assay of histone tail modifications at CLU promoters (P1 and P2) shows that treatment of prostate cancer cells with AZDC-TSA causes enrichment of Histone3(Lys9)acetylated (H3K9ac) and reduction of Histone3(Lys27)trimethylated (H3K27me3), inducing active transcription of both CLU variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/25464035 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v5.0.0/void/BEFREE http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v5.0.0/void/BEFREE http://purl.org/pav/importedOn 2017-02-19 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/dc/terms/created 2017-10-17T13:18:12+02:00 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v5.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP1256870.RAVku3iGodY4Cr866lg3pPU2BrzgKz_VTO2-BSi-0L2Fo http://purl.org/pav/version v5.0.0.0 http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v5.0.0