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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAVe5yC4VXp9AZ2iEXWqa0qp1IYXNaS63p-vwDSkurGcE#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAVe5yC4VXp9AZ2iEXWqa0qp1IYXNaS63p-vwDSkurGcE#_7 http://www.w3.org/ns/prov#value in a substantial proportion of patients with primary breast cancer, and in all patients with ER positive metastatic disease, resistance eventually develops to all strategies that are designed to limit ER activation by oestrogen. 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