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tscript(p(MGI:Foxa2)) -> bp(GOBP:"fatty acid beta-oxidation")
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Approximately 61,000 statements.
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In these mice, adenoviral expression of Foxa2T156A, a nuclear, constitutively active Foxa2 that cannot be inhibited by insulin, decreases hepatic triglyceride content, increases hepatic insulin sensitivity, reduces glucose production, normalizes plasma glucose and significantly lowers plasma insulin. These changes are associated with increased expression of genes encoding enzymes of fatty acid oxidation, ketogenesis and glycolysis.
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Selventa
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